Weight Loss

Garcinia cambogia For Weight Loss

In a study involving 60 obese men and women, the group is given G. cambogia for  eight weeks. And HCA was found to help people lose weight in comparison to placebo group who took dummy supplement.

One study on male Zucker obese rats showed the effectiveness of this herb for suppressing body fat accumulation. This study included the safety at high dosage with histopathological examination. The dose at 389 mg per kg of body weight per day (Too much than the normal dosage) was found safe and without causing toxic effects on testicles. This study suggested that G. cambogia extract inhibits the accumulation of lipids in fat cells in adipose tissue (Fat droplet size reduced from 30-40 microns to 10-20 microns).

Another study from Molecular Cell Biochemistry proved again in a 90 day study its efficacy in overweight management. The 60% HCA containing extract of Garcinia cambogia was found to promote fat oxidation, enhance serotonin release and its availability in brain, normalization of lipid profiles and reduction of serum leptin levels in overweight individuals. This study established its safety on many criteria as acue oral, dermal and eye irritation toxicities, mutation studies and mouse lymphoma tests.

HCA, the bio-available extract of Garcinia cambogia found safe for human use. This study was conducted to find out the effects of HCA on body weight and abdominal fat gene expression profile of Sprague-Dawley rats. The study concluded that HCA is found effective for restricting body weight gain in rats. However the plasma leptin levels were unaffected and abdominal fat leptin levels were lowered.

Another study found garcinia extract to be a potent inhibitor of ATP Citrate lyase, the cellular enzyme that hastens the break of citrate to Acetyl coenzyme A and oxalocitrate. This inhibition of the enzyme reduces the availability of Acetyl coenzyme A for fatty acid and lipid synthesis from spare carbohydrates like starches and sugars. This helps directly in restricting the weight gain and induces weight gain.

This study evaluated the effects of 3.3% garcinia extract on serum leptin and insulin. The findings suggested that this herbal supplement has leptin like activity and improved glucose metabolism.

Another reputed and controversial  study at Obesity Research Center at Columbia University, found no significant differences in estimated percentage of body fat mass loss between treatment groups, and the fraction of subject weight loss as fat was not influenced by treatment group. This study concluded that Garcinia cambogia failed to produce significant weight loss and fat mass loss beyond that observed with placebo.

Later some researchers pointed that the high fiber diet in this study might have interfered with absorption of HCA and monitoring HCA concentration in blood during the study period might resolve this controversy. Plus HCA works best when we are taking a noraml fat diet and not starving ourselves with greatly reduced fat intake


Mechanism Of Action Of Garcinia cambogia:

  1. Animal studies indicate its action is mediated by two pathways. HCA works by blocking lipogenesis or conversion of starches and sugars (Excess of Carbohydrates) into fat that is stored and increases our weight.
  2. This herbal supplement promotes the oxidation of lipids and spares carbohydrates. This action will result in lower blood levels of cholesterol and lipid i.e. a better lipid profile.
  3. The glucose or its stored form glycogen is promoted. As excess of glucose is spared from conversion to fat, this excess glucose is mediated by gluconeogenesis pathway to form glycogen.
  4. Glycogen signals the brain satiety center that sufficient food has been taken. So glycogen production with this herb further suppresses appetite.
  5. Another of its action is on Central Nervous system. It raises the levels of Serotonin like brain neurotransmitters that has role in regulation of appetite.
  6. This herb promotes thermogenesis process i.e. body's production of heat. This burns more calories and excess of stored fat.

Garcinia cambogia is a small fruit, found in India and Southeast Asia. It is used extensively as a condimental in Indian cuisine.

Garcinia cambogia's active ingredient is Hydroxycitric acid (HCA), which is extracted from the rind of the fruit.

Clinical studies indicate that HCA is a powerful anti-obesity and weight loss agent. HCA restricts the conversion of carbohydrates to fat by blocking the enzymes responsible for fat synthesis. HCA helps suppress food intake by sending signals of "fullness" to the brain.

Research indicates that HCA supplementation, even when combined with a normal diet, may result in more than 50% greater weight loss, compared to placebo groups. In one particular study subjects taking HCA for 8 weeks decreased body weight and BMI by 5.4%. In addition, they also experienced improved blood lipid profiles.

More recently, it has been proved that Garcinia cambogia has a hepato protective ability against external toxins, such as alcohol.
A recent study showed that Garcinia prevented liver cells from becoming fibrotic and stopped cell damage caused by high blood lipid levels.